Following last week’s draw with Durham, City were looking to revitalise their promotion challenge and were on top from kick-off.
The hosts made their early dominance count as first Jodie Brett launched a powerful strike from outside the area that cannoned into the net off of the crossbar.
And the Vixens were 2-0 by the 11th minute after Deanna Cooper diverted a Claire Emslie ball past Sophie Harris and into the Bees’ goal.
The visitors grew into the half but were unable to trouble Caitlin Leach, while City Women continued to look dangerous in possession.
The Bees almost clawed a goal back in the second half after Eva Popadinova sent a teasing ball to the back post, but Ashleigh Goddard could only send her header over the bar.
But 15 minutes from time, City grabbed their third when Charlie Estcourt spotted Harris off her line and executed a lob from 20 yards out.
Brett 6, OG Cooper 11, Estcourt 78
Bristol City (4-2-3-1): Caitlin Leach, Megan Alexander, Grace McCatty, Chloe Arthur, Olivia Ferguson, Claire Emslie, Flo Allen, Jodie Brett (c), Charlie Estcourt, Frankie Brown, Georgia Evans
Substitutes: Hayley Ladd for Brown 72, Paige Sawyer for Ferguson 77, Ellie Willson for Brett 83
Substitutes not used: Hannah Reid, Rhian Cleverly, Katie Jones
London Bees (4-2-3-1): Sophie Harris, Dani Scanlon, Deanna Cooper, Emma Beckett, Aoife Hurley, Rebecca Anderson, Ashleigh Goddard (c), Nikki Watts, Jo Wilson, Eva Popadinova.
Substitutes: Sydney Hinchliffe for Dani Scanlon 67, Evie Clarke for Howells 80
Substitutes not used: Imogen Riches, Holly Greenwood, Andria Georgiou, Merrick Will, Bethan Davies
Referee: Rob Cockle
Attendance: 523